This week on NephTrials we will discuss the PROTECT-V trial, a platform trial for preventing COVID-19 infections in the vulnerable kidney populations.
Dialysis dreams and sleepless realities: the SLEEP-HD trial
The SLEEP-HD Visual Abstract
Check out the dreamy Visual Abstract by Cristina Popa
Any sleep potion for insomnia in patients on hemodialysis?
🤔 Trainee Love and Breakup Letters to NephSIM
Trainee Love and Breakup Letters to NephSIM: A Free, Mobile-Optimized, Nephrology Teaching Tool (Fattah, CJASN 2023)
🤔 Does BP lowering matter for the kidneys after all?
Intensive BP Control in Patients with CKD and Risk for Adverse Outcomes (Ku, JASN 2023)
🤔 AT receptor action and dementia
Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2 and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries (Marcum, JAMA Open Network 2022)
🤔 Starting ARB in hospitalized COVID, an RCT
Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial (Jardine, The BMJ 2022)
🤔 Empagliflozin in acute decompensated heart failure
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (Voors, Nature Medicine 2023)
🤔 Timing of BP medications, aka chronotherapy
Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial (Mackenzie, The Lancet 2023)
🤔 Spooky sodium, not so spooky
Tissue sodium excess is not hypertonic and reflects extracellular volume expansion (Rossitto, Nature Communications 2020)
🤔 Coffee and the kidneys
CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction (Mahdavi, JAMA Network Open 2023)
🤔 Improving decision making in CKD
Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease (Ladin, Annals Int Med 2023)
🤔 Hypothermia or machine perfusion for kidney transplant?
Hypothermia or Machine Perfusion in Kidney Donors (Malinoski, NEJM 2023)
🤔 Covered Stent for AVF, An RCT
Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis (Dolmatch, Kidney International 2023)
🤔 Yet another race-free GFR equation, this one for transplant!
Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study (Raynaud, BMJ 2023)
🤔 Another GFR equation, this one is from Europe
Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex (Pottel, NEJM 2023)
🤔 Heterogeneity in BP response
TheHeterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A randomized clinical trial (Sundstrom, JAMA 2023)
🤔 Epo production in kidneys
The transcriptional and regulatory identity of erythropoietin producing cells (Kragesteen, Nature Medicine 2023)
🤔 Precision diagnostics of kidney allograft biopsies
An automated histological classification system for precision diagnostics of kidney allografts (Yoo, Nature Medicine 2023)
🤔 Screening for albuminuria is cost-effective
Population-Wide Screening for Chronic Kidney Disease: A Cost-Effectiveness Analysis (Cusick, Annals Int Med 2023)