The Filtrate (minus Matt) gather to talk about the Deep Mind trial on predicting AKI. For the first time the Filtrate invited a guest, Perry Wilson, to help them navigate the trial.

Cast:

Joel Topf

Jennie Lin

Swapnil Hiremath

Perry Wilson

Samira Farouk

Show Notes:

A clinically applicable approach to continuous prediction of future acute kidney injury. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+clinically+applicable+approach+to+continuous+prediction+of+future+acute+kidney+injury#

Deep Mind National Health services scandal https://www.telegraph.co.uk/technology/2017/07/03/googles-deepmind-nhs-misused-patient-data-trial-watchdog-says/

KDIGO AKI guidelines (PDF) https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf

Frank Harrell on the value of continuous variables http://biostat.mc.vanderbilt.edu/wiki/Main/CatContinuous

Thanks. Start with chapter 4 of https://t.co/nwJdNoBtU6 and https://t.co/FQh46EFqdK and my blog articles on https://t.co/8sdCD3RJoQ related to medical decision making
— Frank Harrell (@f2harrell) September 25, 2019

Wilson’s AKI Alert trial published in The Lancet, Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. http://www.nephjc.com/aki-alert

The NINJA trial http://www.nephjc.com/news/2016/8/3/ninja-using-technology-to-prevent-acute-kidney-injury?rq=ninja

The end of EPICparodyEMR: https://twitter.com/EPICEMRparody/status/1178788488881299457?s=20

Folks. It’s been fun. I think I’m done here for awhile (maybe forever). Things are stale. No new ideas. Actually blocked some people who annoyed me today. That means it’s time to turn off the screens and play with children and puppies.

Bye for now. Hope I made you smile. pic.twitter.com/f7L6CLsD5t
— EPICparodyEMR (@EPICEMRparody) September 30, 2019

EPICparodyEMR on Explore the Space: https://www.explorethespaceshow.com/podcasting/epicparodyemr-on-electronic-medical-records/

Tweet where Nassim Nicholas Taleb calls Swap an imbecile:

Imbecile, please show with precision where "he is wrong". With precision.
— Nassim Nicholas Taleb (@nntaleb) September 29, 2019

Blood Pressure Medicines for Five Years to Prevent Death, Heart Attacks, and Strokes. https://www.thennt.com/nnt/anti-hypertensives-to-prevent-death-heart-attacks-and-strokes/

NNT is SPRINT: In participants assigned to intensive BP lowering, major adverse cardiovascular events were reduced by 25% (5.2% v. 6.8%; hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.64–0.89; number needed to treat [NNT] of 62 over 3 yr) and all-cause mortality was reduced by 27% (3.3% v. 4.5%; HR 0.73, 95% CI 0.60–0.90; NNT of 90 over 3 yr).

NNT is highly misleading when assessing chronic disease prevention. https://www.ncbi.nlm.nih.gov/pubmed/25027390

Washington University School of Medicine establishes Division of Physician-Scientists https://medicine.wustl.edu/news/school-of-medicine-establishes-division-of-physician-scientists/

Physician scientists in the NEJM https://www.nejm.org/doi/full/10.1056/NEJMp1904482

NYT article on Physician Scientists: https://www.nytimes.com/2019/09/23/opinion/doctor-scientist-medical-research.html

brussels.sprout on Instagram https://www.instagram.com/brussels.sprout/?hl=en

Superintelligence by Nick Bostrom https://www.amazon.com/Superintelligence-Dangers-Strategies-Nick-Bostrom/dp/1501227742

Amazon bulk powdered cheese: https://www.amazon.com/s?k=powdered+cheese&ref=nb_sb_noss