This is a special episode of Freely Filtered that focused on one of the most important topics facing nephrology today, the use of race in the creatinine eGFR formulas
The Filtrate:
Matt Sparks
Joel Topf
Swapnil Hiremath
Samira Farouk
Jennie Lin
And three special guests:
Carina Seah a second year MD PhD student Mt Sinai who led the initiative to remove race from the eGFR formulas
Poyan Mehr, founder of GlomCon and author of this post on the use of race in eGFR estimating formulas.
Deidra Crews Associate professor of Medicine and researcher in health disparities.
Show Notes:
Petition for Removal of “Race Correction” in eGFR at Mount Sinai https://docs.google.com/document/d/1vJCwVndyzemWCx8RXZLvLm6JLuFN7NdgEFVCFaDnSOk/edit
Dr Murphy, Dean For Clinical Integration And Population Health. Professor And System Chair. https://icahn.mssm.edu/profiles/barbara-murphy
The Bowman Society at the University of Chicago. I can not find a recording of the webinar https://pritzker.uchicago.edu/resources/bowman-society
Social Determinants of Racial Disparities in CKD https://jasn.asnjournals.org/content/27/9/2576
Socioeconomic Disparities in Chronic Kidney Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291541/
Shortcomings of the current GFR estimating equations https://pubs.glomcon.org/archives/1491
Alan S Go’s work on eGFR, hospitalization and death: https://www.nejm.org/doi/full/10.1056/nejmoa041031
Tangri Kidney Failure Risk Calculation https://kidneyfailurerisk.com
De-adjusting for body surface area: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756662/
2018 Nature Reviews Nephrology Porrini Estimated GFR: time for a critical appraisal https://www.nature.com/articles/s41581-018-0080-9
Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C https://www.nejm.org/doi/full/10.1056/nejmoa1114248
Transdermal Measurement of Glomerular Filtration Rate in Mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235579/
Worldwide Frequencies of Apolipoprotein L1 Renal Risk Variants https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482949/
Health Affairs Blog about when and how to measure race in research: https://www.healthaffairs.org/do/10.1377/hblog20200630.939347/full/
ASN Kidney Stars https://www.asn-online.org/grants/travel/details.aspx?app=MSR