ADVOR turns the practice of sequential nephron blockade on its head by blocking the proximal tubule before the loop of Henle. Does it work? Join The Filtrate as we dissect the latest diuretic RCT.
The Filtrate:
Joel Topf
Jordy Cohen
Nayan Arora
Sophia Ambruso
Special Guests:
Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours.
David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute.
Editor:
Joel Topf
Show Notes:
Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS Trial)
Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure (The UNLOAD trial)
Diuretic Strategies in Patients with Acute Decompensated Heart Failure (The DOSE Trial)
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure (The 3T Trial)
Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the AHA/ACC Heart Failure Guidelines (7.2)
Three important acute decompensated heart failure with SGLT2i:
Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure (SOLOIST-WHF Trial)
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (The EMPULSE Trial)
Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)
Cardiologist Sues Epic Over Copyright Infringement
Outcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis.
Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance (PubMed)
Efficacy and Safety of Spironolactone in Acute Heart Failure (ATHENA Trial)
Joel with a video on acetazolamide for altitude sickness.
The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)