The Filtrate (minus Samira) gather to talk about predicting the natural (or not so natural history) of IgA nephropathy.
Cast:
Joel Topf
Jennie Lin
Matt Sparks
Swapnil Hiremath
Show Notes:
Levi Strauss: https://www.biography.com/fashion-designer/levi-strauss
Levey MDRD study: https://www.ncbi.nlm.nih.gov/pubmed/10075613
ADPKD Total Kidney Volume: https://www.nejm.org/doi/10.1056/NEJMoa054341
Halt PKD: https://www.nejm.org/doi/full/10.1056/nejmoa1402685
Tempo 3:4 Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1205511
Description description of IgA nephropathy by Berger and Hiunglais: https://www.ncbi.nlm.nih.gov/pubmed/4180586
The reprint in JASN in 2000 with commentary as part of the Milestones in Nephrology series: https://jasn.asnjournals.org/content/jnephrol/11/10/1957.full.pdf JASN supplies an English translation from the original French.
Nice reference from JASN backing up Matt’s assertion that preeclampsia and not IgA nephropathy is the most common glomerular disease in the world: https://jasn.asnjournals.org/content/18/8/2281
Description of the Singapore Army screening recruits from the Oxford Textbook of Clinical Nephrology: https://books.google.com/books?id=fVItBQAAQBAJ&lpg=PA485&ots=JRoOnUnleT&dq=singapore%20kidney%20biopsy%20army&pg=PA485#v=onepage&q&f=false
Description of the Japanese glomerulonephritis screening program: https://cjasn.asnjournals.org/content/2/6/1360
Swapnil’s studies on autopsy studies:
Finland: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC501386/
Japan: https://www.ncbi.nlm.nih.gov/pubmed/12753320/
Nephrology Secrets, either one of the best or the best nephrology textbooks ever: https://www.amazon.com/Nephrology-Secrets-Book-Edgar-Lerma-ebook/dp/B079TSYNQW/ref=sr_1_1
TESTING Trial on NephJC: http://www.nephjc.com/news/2017/8/28/testing
Stop-Iga Trial on NephJC: http://www.nephjc.com/iga-nephropathy
Testing Trial two: Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study Low Dose Study: https://clinicaltrials.gov/ct2/show/NCT01560052
MEST Score versus MEST-C in NephJC: http://www.nephjc.com/news/2016/10/16/do-crescents-matter-for-iga-nephropathy
Nice discussion of the statistical tests during the Tweet Chat by people who know their stats (I.e. not Joel): https://twitter.com/NephJC/status/1133546750814367746
Tweet-length description of IDI: https://twitter.com/kiwiskiNZ/status/1133595698929098752
Assessing the performance of prediction models: a framework for traditional and novel measures. https://www.ncbi.nlm.nih.gov/pubmed/20010215/
Net Reclassification Indices for Evaluating Risk-Prediction Instruments: A Critical Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918180/
Predicting Progression in CKD: Perspectives and Precautions https://www.ajkd.org/article/S0272-6386(15)01413-4/abstract
The Article by Nancy Cook in Circulation that Jennie was talking about: Use and misuse of the receiver operating characteristic curve in risk prediction. https://www.ncbi.nlm.nih.gov/pubmed/17309939
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens https://www.nature.com/articles/ng.3118
Genome-wide polygenic risk predictors for kidney disease https://www.nature.com/articles/s41581-018-0067-6
Where does Matt find minutia like the grams of IgA produced a day? Here: https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130216
Animal models of IgA nephropathy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337240/
Matt’s Book Originals: https://www.amazon.com/gp/product/014312885X/ref=dbs_a_def_rwt_bibl_vppi_i1
Eric Neilson, Dean of Northwestern University https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=23239
Brussels sprout Insta-famous dog and future dean of the medical school: https://www.instagram.com/brussels.sprout/?hl=en
Josh Farkas Rantorial about Contrast Nephropathy: https://twitter.com/PulmCrit/status/1134922050794139648
Swapnil’s Tweetorial about Contrast Nephropathy: https://twitter.com/hswapnil/status/1133906398096609280
Tukaram’s pic of NEJM’s progression from Contrast Induced Nephropathy to Contrast Associated Nephropathy: https://twitter.com/tukaramj/status/1135214980985266178
Zero sodium dialysate for heart failure? https://twitter.com/i/moments/1134811009217155072