It was just the boys for the podcast this episode on the CRIC study of NSAID and opioid use in CKD and its affect on CKD outcomes. This was published in AJKD.
The Filtrate:
Joel Topf
Swapnil Hiremath
Matt Sparks
And special guests:
Joshua Waitzman, third year nephrology fellow at Beth Israel
Harold “Harv” Feldman. Editor in Chief at AJKD and national study chair of CRIC and principal investigator of the Scientific and Data Coordinating Center of the CRIC Study. https://www.dbei.med.upenn.edu/bio/harold-i-feldman-md-msce
Show Notes:
CRIC: Chronic Renal Insufficiency Cohort http://www.cristudy.org/
NSAID Studies at NephJC:
Precision: http://www.nephjc.com/news/2017/1/20/hwgrko70d3z88djtjcmzvwpzlirm6c?rq=precision
Army of NSAIDs: http://www.nephjc.com/news/nsaids and the podcast (from before the name Freely Filtered, http://www.nephjc.com/freelyfiltered/2019/3/24/nephjc-drive-time-001-an-army-of-nsaids)
And this week’s study: CRIC: http://www.nephjc.com/news/nsaids-vs-opioids
Methods at 16:55
Matt had to get a mouse study 🐁 in, so here it is: Renal Abnormalities And An Altered Inflammatory Response In Mice Lacking Cyclooxygenase Ii https://www.nature.com/articles/378406a0
The Beth Israel Flex, “The first time I read the paper…”
Results at 32:46
Discussion 48:13
Josh King on opioids being nephrotoxic: https://twitter.com/nephrotox/status/1260400636253921281?s=20
This Week in Covid
The fight over round spikey things.
German autopsy study showing SARS-CoV2 in the kidney: https://www.nejm.org/doi/full/10.1056/NEJMc2011400
Kidney International walking back some previous declarations of what they are seeing on EM: https://twitter.com/Kidney_Int/status/1263641195416150018?s=20
MedRxIV on AKI with COVID-19 at Mount Sinai Medical Center: https://www.medrxiv.org/content/10.1101/2020.05.04.20090944v1
Juan Carlos discussing etiologies of AKI in COVID-19 outbreak in New Orleans.
https://kidney360.asnjournals.org/content/early/2020/05/13/KID.0002652020
Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext
Friend of the Podcast, Kenar Jhaveri and his data on COVID19 and AKI in Kidney International. https://www.kidney-international.org/article/S0085-2538(20)30532-9/fulltext