Freely Filtered 020: SGLT2i are diuretics, but not like any other diuretics

Episode 020 The Filtrate is joined by Sadiya Kahn and Paul Welling to discuss the Circulation article that examined the diuretic properties of SGLT2i.

The Filtrate:

Joel Topf

Swapnil Hiremath

Samira Farouk

Matt Sparks

And special guests:

Sadiya Kahn a heart failure specialist at Northwestern University. @HeartDocSadiya

and

Paul Welling a professor of medicine and nephrology at Johns Hopkins. @PAWellingMD

Show Notes:

The Study: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.120.045691

Coverage at NephJC: http://www.nephjc.com/news/sglt2mechanism

Diuretics for heart failure NEJM Review article: https://www.nejm.org/doi/full/10.1056/nejmra1703100

Don’t say renal: https://www.kidney-international.org/article/S0085-2538(20)30233-7/fulltext?mobileUi=0

Sanjiv “We pronounce HFpEF huff-puff” Shah, MD https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16814 and https://asecho.org/wp-content/uploads/2016/02/Shah-HFpEF.pdf

Huff Puff is like fetch. It is not going to happen. https://www.youtube.com/watch?v=Pubd-spHN-0

Did he have buttons? https://ajkdblog.org/2019/06/17/muscle-relaxant-use-in-dialysis/ 

Rate My Room: https://twitter.com/ratemyskyperoom?lang=en

Review on Renal Glucosuria from CJASN: https://cjasn.asnjournals.org/content/5/1/133 and another from the National Organizations of Rare Disorders: https://rarediseases.org/rare-diseases/renal-glycosuria/

Mechanism of Impaired Natriuretic Response to Furosemide during Prolonged Therapy: https://pubmed.ncbi.nlm.nih.gov/2811065/

Two studies that showed drops in BNP with SGLT2i

DAPA HF: https://www.nejm.org/doi/full/10.1056/NEJMoa1911303

DEFINE HF showing nice reduction BNP with dapagliflozen: https://pubmed.ncbi.nlm.nih.gov/31524498/?dopt=Abstract

Copeptin, what is it? https://pubmed.ncbi.nlm.nih.gov/18291667/?dopt=Abstract 

SIADH treatment with empagliflozen: https://jasn.asnjournals.org/content/31/3/615.abstract and it is JASN not CJASN. My bad.

EVEREST. Tolvaptan for heart failure: https://jamanetwork.com/journals/jama/fullarticle/206251 

Remdesivir placebo controlled RCT: https://www.nejm.org/doi/full/10.1056/NEJMoa2007764

Joel’s Remdesivir study: https://www.nejm.org/doi/full/10.1056/NEJMoa2007016

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19: https://www.nejm.org/doi/full/10.1056/NEJMoa2015301 

Swap showing a lot of skepticism to the Lancet HCQ data even before the retraction (which happened after this recording) https://www.the-scientist.com/news-opinion/lancet-retracts-surgispheres-study-on-hydroxychloroquine-67613

Baclofen is dangerous https://www.kidney-international.org/article/S0085-2538(20)30552-4/abstract