Nefecon, coated budesonide, is the first drug labelled for IgA nephropathy and the approval path, 9-month reduction in proteinuria followed by 2 year GFR data set the stage for the GN renaissance we are currently living through.
The Filtrate:
Joel Topf
Josh Waitzman
With Special Guest:
Brad Rovin (@BradRovin) Chief of nephrology at The Ohio State University Wexner Medical Center, one of the authors of the Nefigard trial.
Koyal Jain (@koyaljainMD) Program director of the GN Fellowship at University of North Carolina
Roger Rodby (@NephRodby) Associate program director of the Rush University Nephrology Fellowship
Editor
Sophia Ambruso
Show Notes
The manuscript (The Lancet | PubMed | NephJC)
The Results of Part A (Kidney Int | PubMed)
Edmund (Ed) Louis memorium by Steve Korbet in KI
Steve Korbet Do not miss this tweet
TESTING Freely Filtered #48 with Sean Barbour
Iptapocan at the World Congress of Nephrology: WCN24-1506 Efficacy And Safety Of Iptacopan In Patients With IgA Nephropathy: Interim Results From The Phase 3 APPLAUSE-IgAN Study
FDA and mandatory post-marketing studies. What happens when the study is negative (or not completed) (UNDARK)
Who should treat lupus nephritis: rheumatologists or nephrologists? (Nature Reviews Nephrology)
Protein and albumin-to-creatinine ratios in random urines accurately predict 24 h protein and albumin loss in patients with kidney disease (PubMed)
MEST Scores in NephJC
Risk scores in IgAN in NephJC
Repeat renal biopsy improves the Oxford classification-based prediction of immunoglobulin A nephropathy outcome (NDT)
Tarpeyo pills 4 mg. Four pills once a day. (WellRx has a picture of the pills)
IgA nephropathy in African Americans: uncommon but possible (PubMed Central)
Aberrantly Glycosylated IgA1 in IgA Nephropathy: What We Know and What We Don’t Know (PubMed Central)
Effectiveness of Mycophenolate Mofetil Among Patients With Progressive IgA Nephropathy (JAMA Network Open)
Tubular Secretions
Joel: Constellation on Apple TV (Wikipedia). Not good. Dune audio books are excellent. (Audible)
Josh: Podcasts about donating a kidney
One Is Enough Podcast (National Kidney Registry)
Donor Diaries (National Kidney Donation Organization)
Roger Iceland (Wikipedia)
Koyal India (Wikipedia)
Brad Fishing in Dubai