On May 24th, at the ERA meeting in Stockholm Sweden (this will not be the last GLP1ra talk at Stockholm), Vlado Perkovic presented the previously spoiled results of FLOW. In addition to simultaneous publication in the NEJM, it made the front page in newspapers around the world. As one headline writer said, “Is there anything Ozempic can’t do?”
The Filtrate:
Joel Topf
Swapnil Hiremath
Josh Waitzman
Nayan Arora
Sophia Ambruso
With Special Guest:
Brendon Neuen Super smart guy and clinical trialist
Vlado Perkovic Lead author of FLOW and friend of NephJC
Editor
Joel Topf
Show Notes
The manuscript (NEJM): Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes
The acronym FLOW from the title: evaluate renal Function with semagLutide Once Weekly (Twitter)
Joel wrote a blog post prior to the FLOW publication to try to set the table: Peeking Inside Schrödinger’s Box
Brendon’s Neuen’s tweet about total versus chronic slope (X | Twitter)
Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity (Science Direct)
Semaglutide and Diabetic Retinopathy Risk in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials (PubMed)
The Efficacy and Safety of the Combination Therapy With GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis (Frontiers in Pharmacology)
Statistical considerations for testing multiple endpoints in group sequential or adaptive clinical trials (PubMed)
Proteinuria Thresholds Are Irrational: A Call for Proteinuria Indexing (Nephron Clinical Practice)
Frank Harrel on why the NNT sucks (data methods)
Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells (PubMed)
Switching Between Glucagon-Like Peptide-1 Receptor Agonists: Rationale and Practical Guidance (PubMed)
Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial (PubMed)
Doctors are like the pyromaniac fireman (PBFluids)
Suggest topics for NephMadness (Twitter)
Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study (CONFIDENCE) (PubMed)
Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial (PubMed)
Spitzer’s involvement in revolutionizing nephrology is part of this lecture I did at the University of Nebraska Diabetes Symposium. (Dropbox: Start on slide 29)
Spitzer Resigns, Citing Personal Failings (New York Times)
Tubular Secretions
Swap: Dumb Money on NetFlix (Wikipedia)
Josh: Hiking Zion National Park (National Park Service)
Sophia: Lost in Space 2018 TV series on NetFlix (Wikipedia)
Nayan: Pelican Hill resort (Website)
Joel: Bodkin
NephJC Summer Book Club: Covenant of Water by Abraham Verghese (Amazon)