The biggest splash of Kidney Week 2021 was Agarwal’s presentation at the Late Breaking and High Impact Session along with simultaneous publication in the NEJM of CLICK—chlorthalidone in CKD 4. Dr. Agarwal joins The Filtrate to talk about the trial.

The Filtrate:

Joel Topf

Swapnil Hiremath

Jennie Lin (who was only there because her plans got boxed by covid)

Jordy Cohen

Josh Waitzman

Special Guest:

Rajiv Agarwal (@AgarwalRajivMD)

Editor:

Joel Topf

Show Notes:

NephJC discussion of CLICK: http://www.nephjc.com/news/click4chlorthalidone

CLICK Visual abstract: http://www.nephjc.com/news/2021/12/7/the-click-visual-abstract

Hawthorne effect: https://en.wikipedia.org/wiki/Hawthorne_effect

A nice discussion run in periods in clinical trials: http://www.nephjc.com/news/run-in-period

The ABCD trial Agarwal used to describe the need for a beta blocker to enroll in the trial, but it looks like a review article https://pubmed.ncbi.nlm.nih.gov/12574784/

Canadian trial showing that atenolol did as well as evidence based beta blockers: https://pubmed.ncbi.nlm.nih.gov/31495887/ Associated editorial by Agarwal: https://pubmed.ncbi.nlm.nih.gov/31578572/

Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate by Mark A Peterzan https://pubmed.ncbi.nlm.nih.gov/22547443/

HCTZ vs Chlorthalidone compete to the death: VA CSP Study No. 597: Diuretic Comparison Project https://www.research.va.gov/programs/csp/597/default.cfm

Effectiveness versus Efficacy Trials: https://www.ncbi.nlm.nih.gov/books/NBK44024/

Foundation on Apple TV+: https://www.indiewire.com/2021/09/foundation-review-apple-tv-plus-sci-fi-adaptation-1234666972/

The Expanse on Amazon Prime: https://en.wikipedia.org/wiki/The_Expanse_(TV_series)

The Beatles: Get Back on Disney+: https://en.wikipedia.org/wiki/The_Beatles:_Get_Back

School of chocolate on Netflix: https://www.themarysue.com/school-of-chocolate/

And Just Like That... on Disney+: https://en.wikipedia.org/wiki/And_Just_Like_That...

Past-president of AHA forced to make a statement about the Sex and the City episode: https://twitter.com/NMCardioVasc/status/1471627453885997068 https://twitter.com/NMCardioVasc/status/1471817955344371717

Peter Noth is a bad guy and how Peloton dealt with this. https://variety.com/2021/digital/news/peloton-deletes-chris-noth-ad-sexual-assault-allegations-1235135264/

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