We love Kidney Week and the quintessential event at Kidney Week is the Late Break and High Impact Clinical Trial Sessions. Here we see the cutting edge of science revealed. We get to be first when years of work are revealed to the world. And one of the coolest ways for a study to be revealed is with simultaneous publication in a high-impact journal.
Freely Filtered is proud to get to play a role in one of these moments. Amit Garg, friend of the Pod, invited Freely Filtered into the tent to record a podcast on his High Impact and Late Breaking Clinical Trial for simultaneous release with his presentation.
Here is that podcast…
How do we move the needle on living donor transplants? The EnAKT LKD Cluster Randomized Clinical Trial takes its shot
The Filtrate:
Joel Topf
Swapnil Hiremath
Sophia Ambruso
AC Gomez
With Special Guest:
Amit Garg (@AmitXGarg) Nephrologist at Western University, London, and lead PI of the EnAKT LKD trial.
Susan Q. McKenzie (LinkedIn) Co-Founder & Chair, Transplant Ambassador Program. President of the Kidney Patient and Donor Alliance of Canada.
Editor:
Joel Topf
Show Notes:
Late Braking and High Impact Clinical Trial press release
MyTEMP trial Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial (PubMed | NephJC | Freely Filtered)
Transplant is cheaper! An economic assessment of contemporary kidney transplant practice (PDF)
Transplant is better! Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis (PubMed)
Transplant disparities Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014 (PubMed)
MUC1 Kidney Disease Autosomal Dominant Tubulointerstitial Kidney Disease: An Emerging Cause of Genetic CKD (Kidney International Reports)
This study has all the adjectives: “We conducted a pragmatic, two-arm, parallel-group, open-label, registry-based, superiority, cluster- randomized clinical trial.”
Explore Transplant by Amy Waterman, PhD
Kidney Failure Risk Equation A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure (JAMA | Calculator)
The complete protocol A Quality Improvement Intervention to Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) in Patients With Chronic Kidney Disease: Clinical Research Protocol of a Cluster-Randomized Clinical Trial (PDF)
Pre-published statistical plan Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD): Statistical Analysis Plan of a Registry-Based, Cluster-Randomized Clinical Trial (PubMed)
Hawthorne effect (Wikipedia)
The Advancing American Kidney Health Initiative “Aim for 80% of new American ESRD patients in 2025 receiving either home dialysis or a transplant” (NKF)
Tubular Secretions
Swapnil The Time Travelers Wife by Audrey Niffenegger (Wikipedia) and HBO movie of the same name (Wikipedia).
Sophia The Wheel of Time streaming on Amazon (Wikipedia) based on the series of books of the same name by Robert Jordan and Brandon Sanderson.
Susan The Woman Who Loved Giraffes movie (Website)
Amit Canadians cannot get Visas to visit India (Reuters)
AC Eagles are good at Football (Fox Sports) and Alport Connect Meeting in San Diego (Alport Syndrome Foundation Website)
Joel Live podcast recording at Kidney Week (NephJC)
Watch the LBCT presentation with a shoutout to the pod below