Background
Brian Rifkin
KDIGO 2025 ADPKD Guidelines Review

This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, and patients. The guidelines incorporate ADPKD-specific care as well as many general CKD management practice points.


KDIGO 2025 ADPKD Guidelines Review
Background
Cristina Adriana Popa
REGENCY: A B-Cell Super Destroyer in Lupus

This week, we will celebrate in advance World Kidney Day by discussing the results of OBInutuzumab in active lupus nephritis. The LUNAR trial (rituximab versus placebo) was “almost” positive, but not quite there. Would Obi overpower its cousin ritux? ✨

REGENCY: A B-Cell Super Destroyer in Lupus
Background
Cristina Adriana Popa
Hunting Primary Hyperaldosteronism: are MRAs a ...

This week, we will continue with February’s aldosterone leitmotif: do mineralocorticoid receptor antagonists (MRAs) truly blind the diagnostic in unilateral hypraldosteronism? Is this the article the mythbuster? Draw your own conclusions

Hunting Primary Hyperaldosteronism: are MRAs a blindfold in adrenal vein sampling?
Background
Brian Rifkin
Undercover Aldosterone

This week, we will discuss the origins of primary hyperaldosteronism in normotensive patients. Could this undetected anomaly be the cause of idiopathic hypertension and CKD?

Undercover Aldosterone
Background
swapnil hiremath
HOPE-ing and Coping with Pain in Dialysis

This week, we will discuss the HOPE trial - no not that one - the one in dialysis that was a LBCT in 2024. Should we look beyond analgesics to non-pharmacological options more seriously?

HOPE-ing and Coping with Pain in Dialysis

DIvya Bajpai

Obinutuzumab en Nefritis Lúpica: ¿Un Nuevo Horizonte?

El estudio REGENCY, un ensayo fase 3, doble ciego y controlado con placebo, evaluó la eficacia y seguridad de obinutuzumab en pacientes con nefritis lúpica activa. ¿Es realmente eficaz y seguro en la depleción de células B en LN?
🔥 Hoy en #NephJC analizamos cómo estos hallazgos impactarán el futuro del tratamiento en la nefritis lúpica. 🕘 Únete a la discusión a las 9 pm EST en BlueSky🦋!

Mineralocorticoid Receptor Blockade prior to Adrenal Venous Sampling for PA - The Visual Abstract

Do Mineralocorticoid Receptor Antagonists Preclude the Identification of Unilateral Primary Aldosteronism at Adrenal Venous Sampling?

Guidelines recommend withholding MRAs prior to PA subtyping by AVS. Is it worth the risk of hypokalemia and hypertension? NSMC Faculty Dr Divya Bajpai answers with a crisp VA